U-Blot® IGF-IR Receptor β (Phospho Tyr1135) Rabbit mAb
Ucallm_WR5725-50
Price range: $268.00 through $328.00
Product details
Background:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
Specifications
| Target | IGF-1R Phospho Tyr1135 |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IF,ELISA |
| MW(Calculated) | 155kD |
| MW(Observed) | 115kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Phospho |
| Modified site | Tyr1135 |
| Recommended Dilution Ratio | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Composition | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification Process | Protein A |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | PT1582R |
| Immunogen | |
| Sequence | |
| Specificity | IGF-IR Receptor β (Phospho Tyr1135) Antibody detects endogenous levels of IGF-IR Receptor β protein only when phosphorylated at Tyr1135.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HRdLA |
| Gene Name | IGF1R |
| Protein Name | IGF-I Receptor β |
| Alias | Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD antigen CD221;[Cleaved into: Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain] |
| Organism-1 | Human |
| Gene ID-1 | 3480 |
| SwissProt-1 | P08069 |
| Organism-2 | Mouse |
| GeneID-2 | 16001.0 |
| SwissProt-2 | Q60751 |
| Organism-3 | Rat |
| GeneID-3 | 25718.0 |
| SwissProt-3 | P24062 |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Cellular Localization | Cell membrane ; Single-pass type I membrane protein . |
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