U-Blot® IL-2 Rabbit mAb
Ucallm_WR5223-50
Price range: $268.00 through $328.00
Product details
Background:The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | IL-2 |
| Reactivity | Human |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 18kD |
| MW(Observed) | 14kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1458R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | IL2 |
| Protein Name | Interleukin-2 |
| Other Name | IL2; / Interleukin-2; / IL-2; / T-cell growth factor; / TCGF; / Aldesleukin |
| Species | Human |
| Gene ID | 3558 |
| Uniprot | P60568, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P04351, |
| Species.2 | Rat |
| Gene ID.2 | 116562 |
| Uniprot.2 | P17108 |
| Cellular Localization | Secreted. |
| Tissue Expression | Blood,PCR rescued clones,Placenta,Spleen, |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Graft-versus-host disease;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>PI3K-Akt signaling pathway; / >>C-type lectin receptor signaling pathway; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Intestinal immune network for IgA production; / >>Type I diabetes mellitus; / >>Yersinia infection; / >>Chagas disease; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Autoimmune thyroid disease; / >>Inflammatory bowel disease; / >>Allograft rejection; / >>Graft-versus-host disease |
| Function | Disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4; 16)(q26; p13) with involves TNFRSF17.,Function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family., |
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