Name: U-Blot® Integrin αL Rabbit mAb
SKU: WR5976
Price: 268 USD
Availability: InStock

U-Blot® Integrin αL Rabbit mAb

Ucallm_WR5976-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR5976-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background：
integrin subunit alpha L (ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) , which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands , ICAMs 1-3 (intercellular adhesion molecules 1 through 3) , and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,

Specifications

Size	50μL/100μL
Target	Integrin αL
Reactivity	Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)	129kD
MW(Observed)	180kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM2008R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ITGAL
Protein Name	Integrin alpha-L
Other Name	ITGAL; / CD11A; / Integrin alpha-L; / CD11 antigen-like family member A; / Leukocyte adhesion glycoprotein LFA-1 alpha chain; / LFA-1A; / Leukocyte function-associated molecule 1 alpha chain; / CD11a
Species	Human
Gene ID	3683
Uniprot	P20701,
Species.1	Mouse
Gene ID.1
Uniprot.1	P24063
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein .
Tissue Expression	Leukocytes.
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Rap1 signaling pathway; / >>Cell adhesion molecules; / >>Neutrophil extracellular trap formation; / >>Natural killer cell mediated cytotoxicity; / >>Leukocyte transendothelial migration; / >>Regulation of actin cytoskeleton; / >>Malaria; / >>Staphylococcus aureus infection; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Rheumatoid arthritis; / >>Viral myocarditis
Function	Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,