U-Blot® IRS2 Rabbit mAb
Ucallm_WR5941-50
Price range: $268.00 through $328.00
Product details
Background：
This gene encodes the insulin receptor substrate 2 , a cytoplasmic signaling molecule that mediates effects of insulin , insulin-like growth factor 1 , and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation , as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq , Jul 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | IRS2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 137kD |
| MW(Observed) | 185kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1887R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | IRS2 |
| Protein Name | insulin receptor substrate 2 |
| Other Name | IRS2 |
| Species | Human |
| Gene ID | 8660 |
| Uniprot | Q9Y4H2, |
| Species.1 | Mouse |
| Gene ID.1 | 384783 |
| Uniprot.1 | P81122 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Blood,Epithelium,Platelet, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway |
| Research Areas | >>cGMP-PKG signaling pathway; / >>FoxO signaling pathway; / >>Autophagy - animal; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Insulin signaling pathway; / >>Adipocytokine signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Type II diabetes mellitus; / >>Insulin resistance; / >>Non-alcoholic fatty liver disease; / >>Growth hormone synthesis, secretion and action; / >>Alzheimer disease; / >>MicroRNAs in cancer |
| Function | Function:May mediate the control of various cellular processes by insulin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain., |
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