SKU: WR5911 Categories: ,

U-Blot® MCT4 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5911-50
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Product details

Background:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family , which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics , which are related to the metabolic requirements of the tissues in which it is found. The MCTs , which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654) , are characterized by 12 predicted transmembrane domains (Price et al. , 1998 [PubMed 9425115]) .[supplied by OMIM , Mar 2008] ,

Specifications

Size50μL/100μL
TargetMCT4
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)49kD
MW(Observed)43kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1861R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameSLC16A3
Protein NameMonocarboxylate transporter 4
Other NameSLC16A3; / MCT4; / Monocarboxylate transporter 4; / MCT 4; / Solute carrier family 16 member 3
SpeciesHuman
Gene ID9123
UniprotO15427,
Species.1Mouse
Gene ID.180879
Uniprot.1P57787,
Species.2Rat
Gene ID.280878
Uniprot.2O35910
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionHighly expressed in skeletal muscle.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Research Areas>>Central carbon metabolism in cancer
FunctionFunction:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle.,
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