Price range: $268.00 through $328.00
Background:This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer' s and Parkinson' s diseases. There are pseudogenes for this gene on chromosomes 6 , 7 , and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Aug 2012] ,
| Size | 50μL/100μL |
| Target | mtTFA |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 28kD |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2186R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TFAM |
| Protein Name | Transcription factor A mitochondrial |
| Other Name | TFAM; / TCF6; / TCF6L2; / Transcription factor A; / mitochondrial; / mtTFA; / Mitochondrial transcription factor 1; / MtTF1; / Transcription factor 6; / TCF-6; / Transcription factor 6-like 2 |
| Species | Human |
| Gene ID | 7019 |
| Uniprot | Q00059, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P40630 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion |
| Tissue Expression | Lymphocyte ,Pooled ,Uterus , |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Huntington disease;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Apelin signaling pathway; / >>Huntington disease |
| Function | Function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. ,similarity:Contains 2 HMG box DNA-binding domains. ,subunit:Interacts with TFB1M and TFB2M. , |
