Name: U-Blot® NCPR Rabbit mAb
SKU: WR6001
Price: 268 USD
Availability: InStock

U-Blot® NCPR Rabbit mAb

Ucallm_WR6001-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR6001-50

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Product details

Background：
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors , FAD and FMN , which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases , including apparent combined P450C17 and P450C21 deficiency , amenorrhea and disordered steroidogenesis , congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq , Jul 2008] ,

Specifications

Size	50μL/100μL
Target	NCPR
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	77kD
MW(Observed)	77kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:1000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM2011R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	POR CYPOR
Protein Name	NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)
Other Name
Species	Human
Gene ID	5447
Uniprot	P16435,
Species.1	Mouse
Gene ID.1
Uniprot.1	P37040,
Species.2	Rat
Gene ID.2
Uniprot.2	P00388
Cellular Localization	Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side .
Tissue Expression	Aorta endothelial cell,Liver,Lung,Small intestine,
Signaling_pathway
Research Areas
Function	Catalytic activity:NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.,cofactor:FAD.,cofactor:FMN.,Disease:Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].,Disease:Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.,Function:This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,similarity:In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,subcellular location:Anchored to the ER membrane by its N-terminal hydrophobic region.,