U-Blot® P2RY6 Rabbit mAb
Ucallm_WR5412-50
Price range: $268.00 through $328.00
Product details
Background:The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013],
Specifications
| Size | 50μL/100μL |
| Target | P2RY6 |
| Reactivity | Human |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 36kD |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1661R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | P2RY6 PP2891 |
| Protein Name | P2Y purinoceptor 6 (P2Y6) |
| Other Name | |
| Species | Human |
| Gene ID | 5031 |
| Uniprot | Q15077, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9ERK9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q63371 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Placenta, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family., |
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