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Background:D-Lactyllysine (K₍D_x001E_la₎) is the D_x001E_stereoisomer of lysine lactylation, a novel type of lysine acylation post_x001E_translational modification. By conjugating a D_x001E_lactyl group to lysine residues, K₍D_x001E_la₎ is mainly generated via non_x001E_enzymatic pathways from glycolysis byproducts and exists on both histone and non_x001E_histone proteins. It participates in chromatin remodeling, gene transcription, and cellular metabolic stress responses, and is closely associated with tumorigenesis, inflammation, metabolic reprogramming, and other pathological processes, serving as a key target in metabolic_x001E_epigenetic crosstalk research.
