Price range: $288.00 through $368.00
Background:CDC2, also known as CDK1, is a pivotal regulatory protein in the cell cycle process. The activity of CDC2 is controlled through multiple steps, including binding to cyclins and phosphorylation at Thr161. Crucially, the dephosphorylation of CDC2 at Thr14 and Tyr15 by the CDC25 phosphatase is a key step in its activation. Conversely, phosphorylation of CDC2 at these same sites by Wee1 and Myt1 kinases inhibits its activity.
| Target | Phospho-CDC2 (Tyr15) |
| Reactivity | Human, Mouse, Rat |
| Application | WB, IP |
| MW(Calculated) | 34 kDa |
| MW(Observed) | 34 kDa |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Phosphorylation |
| Modification Site | Tyr15 |
| Recommended dilution ratio | WB 1:1000-1:2000; IP 1:50-1:100 |
| Composition | PBS, Glycerol, BSA |
| Purification process | Protein A affinity purification |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles |
| Stability | Stable for 12 months from date of receipt / reconstitution. |
| Concentration | |
| Clonal | Recombinant monoclonal |
| Clone Number | W-R39 |
| Immunogen | polypeptide |
| Gene Name | CDK1 |
| Protein Name | Cyclin-dependent kinase 1 (CDK1/CDC2) |
| Alternative name | CDC2, CDK1, CDC2Y15ph |
| Organism-1 | Human |
| Gene ID | 983 |
| SwissProt-1 | P06493 |
| Cellular Localization | Cytoskeleton, Cytoplasm, Nucleus, Mitochondrion |
