U-Blot® Phospho-Tau (Ser199) Rabbit mAb
Ucallm_WT9103-100
Price range: $288.00 through $368.00
Product details
Background:Promotes microtubule assembly and stability and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Specifications
| Target | Phospho-Tau (Ser199) |
| Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, ICC/IF, FC |
| MW(Calculated) | 79 kDa |
| MW(Observed) | 55 kDa |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Phosphorylation |
| Modification Site | Ser199 |
| Recommended dilution ratio | WB 1:1000-1:3000; IHC-P 1:200-1:1000; ICC/IF 1:50; FC 1:50-1:100 |
| Composition | PBS, Glycerol, BSA |
| Purification process | Protein A affinity purification |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles |
| Stability | Stable for 12 months from date of receipt / reconstitution. |
| Concentration | |
| Clonal | Recombinant monoclonal |
| Clone Number | W-R73 |
| Immunogen | polypeptide |
| Gene Name | MAPT |
| Protein Name | Microtubule-associated protein Tau |
| Alternative name | MAPT, MAPTL, MTBT1 |
| Organism-1 | Human |
| Gene ID | 4137 |
| SwissProt-1 | P10636 |
| Cellular Localization | Membrane, Cytoplasm, Cytoskeleton, Microtubule |
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