Name: U-Blot® PRLR Rabbit mAb
SKU: WR5074
Price: 268 USD
Availability: InStock

U-Blot® PRLR Rabbit mAb

Ucallm_WR5074-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR5074-100

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Product details

Background:This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],

Specifications

Size	50μL/100μL
Target	PRLR
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	70kD
MW(Observed)	95kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:500; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1312R
Immunogen	AA range: 25-234
Specificity	Endogenous
Gene Name	PRLR
Protein Name	Prolactin receptor
Other Name	PRL-R
Species	Human
Gene ID	5618
Uniprot	P16471,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q08501,
Species.2	Rat
Gene ID.2
Uniprot.2	P05710
Cellular Localization	Membrane; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
Tissue Expression	Expressed in breast, placenta, kidney, liver and pancreas.
Signaling_pathway	Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Neuroactive ligand-receptor interaction; / >>PI3K-Akt signaling pathway; / >>JAK-STAT signaling pathway; / >>Prolactin signaling pathway
Function	Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,