Specifications
| Size | 6mL |
| Target | PSAP |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | Recombinant Expression and Affinity purified |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM66R |
| Immunogen | Synthesized peptide derived from human Prostatic Acid Phosphatase(PSAP) AA range:201-300 |
| Specificity | This antibody detects endogenous levels of PSAP |
| Gene Name | ACPP |
| Protein Name | Prostatic Acid Phosphatase(PSAP) |
| Other Name | 5' NT; / 5' nucleotidase; / 5'-NT; / 5'-nucleotidase; / Acid phosphatase prostate; / ACP 3; / ACP3; / acpP; / Ecto 5' nucleotidase; / Ecto-5'-nucleotidase; / PAP; / PPAP_HUMAN; / Prostatic acid phosphatase; / Prostatic acid phosphotase; / Thiamine monophosphatase; / TMPase |
| Species | Human |
| Gene ID | 55 |
| Uniprot | P15309 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Secreted .; [Isoform 2]: Cell membrane; Single-pass type I membrane protein . Lysosome membrane; Single-pass type I membrane protein . Nucleus . Cytoplasm, cytosol . Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). . |
| Tissue Expression | Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues.; [Isoform 2]: Widely expressed. Expressed in the sarcolemma of skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,similarity:Belongs to the histidine acid phosphatase family.,subcellular location:Predominantly localized in the plasma membrane but also detected in intracellular vesicles.,subunit:Homodimer., |
