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Home/Reagents/Antibody/Biosimilar & Bispecific Antibodies/U-Blot® Research Grade Alacizumab
SKU: WA1040 Categories: ,

U-Blot® Research Grade Alacizumab

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$9,999.00

SKU: WA1040-50
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Product details

Background：Alacizumab pegol is an antineoplastic agent. Chemically, it is a pegylated F(ab’)2 fragment of a monoclonal antibody.
• Flk-1/KDR mediates ethanol-stimulated endothelial cell Notch signaling and angiogenic activity., PMID:25322777
• VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial., PMID:37393757
• Vascular endothelial growth factor receptor 2, but not S100A4 or S100A6, correlates with prolonged survival in advanced urothelial carcinoma., PMID:24880461
• Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal., PMID:28410224

Specifications

TargetCD309
ReactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host SpeciesHumanized
IsotypeIgG4
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition0.01M PBS, pH 7.4.
Purification ProcessProtein A/G purified from cell culture supernatant.
Purity>95% purity as determined by SDS-PAGE.
Storage ConditionUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenMammalian Cells
Gene Name
Protein Name
AliasFLK-1, Kinase insert domain receptor, VEGFR2, Fetal liver kinase 1, CD309, Vascular endothelial growth factor receptor 2, Protein-tyrosine kinase receptor flk-1, FLK1, VEGFR-2, KDR
Species
Gene ID-1P35968
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
DescriptionBackground：Alacizumab pegol is an antineoplastic agent. Chemically, it is a pegylated F(ab')2 fragment of a monoclonal antibody.<br>• Flk-1/KDR mediates ethanol-stimulated endothelial cell Notch signaling and angiogenic activity., PMID:25322777<br />• VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial., PMID:37393757<br />• Vascular endothelial growth factor receptor 2, but not S100A4 or S100A6, correlates with prolonged survival in advanced urothelial carcinoma., PMID:24880461<br />• Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal., PMID:28410224<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
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