Name: U-Blot® Research Grade Alemtuzumab
SKU: WA1050
Price: 9999 USD
Availability: InStock

Product details

Background：Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research.
• Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation., PMID:11420384
• Interaction of the human epididymal protein CD52 (HE5) with epididymal spermatozoa from men and cynomolgus monkeys., PMID:9291477
• Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis., PMID:14662784
• A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone., PMID:8418821
• Function of human epididymal proteins in sperm maturation., PMID:9739419
• Epididymal epithelium immortalized by simian virus 40 large T antigen: a model to study epididymal gene expression., PMID:11574662
• Body temperature (37 C) specifically down-regulates the messenger ribonucleic acid for the major sperm surface antigen CD52 in epididymal cell culture., PMID:8828507

Specifications

Target	CD52
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	Human epididymis-specific protein 5, CDW52, CAMPATH-1 antigen, Cambridge pathology 1 antigen, He5, HE5, Epididymal secretory protein E5, CD52, CDw52
Species
Gene ID-1	P31358
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research.<br>• Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation., PMID:11420384<br />• Interaction of the human epididymal protein CD52 (HE5) with epididymal spermatozoa from men and cynomolgus monkeys., PMID:9291477<br />• Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis., PMID:14662784<br />• A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone., PMID:8418821<br />• Function of human epididymal proteins in sperm maturation., PMID:9739419<br />• Epididymal epithelium immortalized by simian virus 40 large T antigen: a model to study epididymal gene expression., PMID:11574662<br />• Body temperature (37 C) specifically down-regulates the messenger ribonucleic acid for the major sperm surface antigen CD52 in epididymal cell culture., PMID:8828507<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function