U-Blot® Research Grade Benralizumab
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$9,999.00
Product details
Background：Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma.
• Benralizumab for the treatment of asthma., PMID:29517082
• Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469
• Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845
• A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease., PMID:23470716
• IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans., PMID:17620072
• Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output., PMID:19654410
• IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils., PMID:26276876
• Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression., PMID:20337967
Specifications
| Target | CD125 |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Humanized |
| Isotype | IgG1-kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R |
| Species | |
| Gene ID-1 | Q01344 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma.<br>• Benralizumab for the treatment of asthma., PMID:29517082<br />• Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469<br />• Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845<br />• A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease., PMID:23470716<br />• IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans., PMID:17620072<br />• Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output., PMID:19654410<br />• IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils., PMID:26276876<br />• Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression., PMID:20337967<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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