Name: U-Blot® Research Grade Burfiralimab
SKU: WA2562
Price: 9999 USD
Availability: InStock

Product details

Background：Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies.
• Roles of vimentin in health and disease., PMID:35487686
• Spatial single-cell protein landscape reveals vimentin^high macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma., PMID:39327501
• Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin., PMID:37641404
• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048
• Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier., PMID:35433510
• Vimentin on the move: new developments in cell migration., PMID:30505430
• Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma., PMID:38901494
• Vimentin as a universal receptor for pseudorabies virus infection in pig and human cells., PMID:39549807
• PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells., PMID:39294765
• Vimentin, colon cancer progression and resistance to butyrate and other HDACis., PMID:27072512

Specifications

Target	Vimentin
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG4-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	Vimentin, VIM
Species
Gene ID-1	P08670
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies.<br>• Roles of vimentin in health and disease., PMID:35487686<br />• Spatial single-cell protein landscape reveals vimentin<sup>high</sup> macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma., PMID:39327501<br />• Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin., PMID:37641404<br />• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048<br />• Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier., PMID:35433510<br />• Vimentin on the move: new developments in cell migration., PMID:30505430<br />• Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma., PMID:38901494<br />• Vimentin as a universal receptor for pseudorabies virus infection in pig and human cells., PMID:39549807<br />• PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells., PMID:39294765<br />• Vimentin, colon cancer progression and resistance to butyrate and other HDACis., PMID:27072512<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function