Background:Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1.
Specifications
Target
CD278
Reactivity
Human
Applications
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species
Humanized
Isotype
half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition
0.01M PBS, pH 7.4.
Purification Process
Protein A/G purified from cell culture supernatant.
Purity
>95% purity as determined by SDS-PAGE.
Storage Condition
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality
Monoclonal
Clone Number
Immunogen
Mammalian Cells
Gene Name
Protein Name
Alias
CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Species
Gene ID-1
Q9Y6W8 & Q15116
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description
Background:Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1.<br>