Name: U-Blot® Bmi-1 Rabbit mAb
SKU: WR4881
Price: 268 USD
Availability: InStock

U-Blot® Bmi-1 Rabbit mAb

Ucallm_WR4881-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4881-50

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Product details

Background:BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],

Specifications

Size	50μL/100μL
Target	Bmi-1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	37kD
MW(Observed)	43kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1051R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	BMI1
Protein Name	Polycomb complex protein BMI-1
Other Name	BMI1; / PCGF4; / RNF51; / Polycomb complex protein BMI-1; / Polycomb group RING finger protein 4; / RING finger protein 51
Species	Human
Gene ID	648
Uniprot	P35226,
Species.1	Mouse
Gene ID.1
Uniprot.1	P25916
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Cytoplasm .
Tissue Expression	Epithelium,Erythrocyte,Muscle,Thymus,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas	>>Signaling pathways regulating pluripotency of stem cells; / >>Transcriptional misregulation in cancer; / >>MicroRNAs in cancer
Function	Disease:Cooperates with the MYC oncogene to produce B-lymphomas.,Function:Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.,PTM:May be polyubiquitinated; which does not lead to proteasomal degradation.,similarity:Contains 1 RING-type zinc finger.,subunit:Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.,

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U-Blot® Bmi-1 Rabbit mAb

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U-Blot® Bmi-1 Rabbit mAb

Product details

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