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Home/Reagents/Antibody/Biosimilar & Bispecific Antibodies/U-Blot® Research Grade Pogalizumab
SKU: WA3372 Categories: ,

U-Blot® Research Grade Pogalizumab

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$9,999.00

SKU: WA3372-50
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Product details

Background：Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response
• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077
• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520
• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560
• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970
• An OX-Tra’Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026
• Entry of betaherpesviruses., PMID:31439151
• OX40 (CD134) and OX40L., PMID:19760068
• Research progress in OX40/OX40L in allergic diseases., PMID:39404736
• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity., PMID:37932534
• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673

Specifications

TargetCD134
ReactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host SpeciesHumanized
IsotypeIgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition0.01M PBS, pH 7.4.
Purification ProcessProtein A/G purified from cell culture supernatant.
Purity>95% purity as determined by SDS-PAGE.
Storage ConditionUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenMammalian Cells
Gene Name
Protein Name
AliasACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134
Species
Gene ID-1P43489
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
DescriptionBackground：Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response<br>• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077<br />• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520<br />• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560<br />• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970<br />• An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026<br />• Entry of betaherpesviruses., PMID:31439151<br />• OX40 (CD134) and OX40L., PMID:19760068<br />• Research progress in OX40/OX40L in allergic diseases., PMID:39404736<br />• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8<sup>+</sup> T-cell immunity., PMID:37932534<br />• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
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