U-Blot® Research Grade Pogalizumab
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$9,999.00
Product details
Background：Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response
• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077
• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520
• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560
• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970
• An OX-Tra’Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026
• Entry of betaherpesviruses., PMID:31439151
• OX40 (CD134) and OX40L., PMID:19760068
• Research progress in OX40/OX40L in allergic diseases., PMID:39404736
• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity., PMID:37932534
• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673
Specifications
| Target | CD134 |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Humanized |
| Isotype | IgG1-kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134 |
| Species | |
| Gene ID-1 | P43489 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response<br>• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077<br />• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520<br />• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560<br />• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970<br />• An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026<br />• Entry of betaherpesviruses., PMID:31439151<br />• OX40 (CD134) and OX40L., PMID:19760068<br />• Research progress in OX40/OX40L in allergic diseases., PMID:39404736<br />• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8<sup>+</sup> T-cell immunity., PMID:37932534<br />• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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