Name: U-Blot® Research Grade Ramatercept
SKU: WA3417
Price: 9999 USD
Availability: InStock

Product details

Background：Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.
• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454
• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826
• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905
• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196
• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042
• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097
• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925
• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254
• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022
• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202

Specifications

Target	GDF-8
Reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Mammalian Cells
Isotype	Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8
Species
Gene ID-1	O14793
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.<br>• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454<br />• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826<br />• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905<br />• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196<br />• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042<br />• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097<br />• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925<br />• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254<br />• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022<br />• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function