Name: U-Blot® Research Grade Tilvestamab
SKU: WA3662
Price: 9999 USD
Availability: InStock

Product details

Background：Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011).
• Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site., PMID:9178760
• Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias., PMID:9130617
• Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors., PMID:36630517
• The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer., PMID:25568918
• Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia., PMID:39395205
• Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain., PMID:8108112
• Serum AXL is a potential molecular marker for predicting COVID-19 progression., PMID:38799467
• Clinical significance of AXL kinase family in gastric cancer., PMID:12168903
• Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells., PMID:21730355
• The genomic structure of the human UFO receptor., PMID:8381225

Specifications

Target	UFO
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Species
Gene ID-1	P30530
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011).<br>• Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site., PMID:9178760<br />• Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias., PMID:9130617<br />• Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors., PMID:36630517<br />• The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer., PMID:25568918<br />• Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia., PMID:39395205<br />• Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain., PMID:8108112<br />• Serum AXL is a potential molecular marker for predicting COVID-19 progression., PMID:38799467<br />• Clinical significance of AXL kinase family in gastric cancer., PMID:12168903<br />• Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells., PMID:21730355<br />• The genomic structure of the human UFO receptor., PMID:8381225<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function