SKU: WM1658R Categories: ,

U-Blot® S100A6 Mouse mAb (Ready to Use)

$168.00

SKU: WM1658R
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Product details

Background:
S100 calcium binding protein A6(S100A6) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008],

Specifications

TargetS100A6
ReactivityHuman
ApplicationsIHC
MW(Calculated)
MW(Observed)
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioReady to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationThe prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
PurificationThe antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage2°C to 8°C/1 year,Ship by ice bag
Concentration
ClonalityMonoclonal
Clone NumberABT-S100A6
ImmunogenSynthesized peptide derived from human S100A6 AA range: 50-90
Sequence
SpecificityThe antibody can specifically recognize human S100A6 protein.
Gene NameS100A6 CACY
Protein NameS100A6
Other NameProtein S100-A6; / Calcyclin; / Growth factor-inducible protein 2A9; / MLN 4; / Prolactin receptor-associated protein; / PRA; / S100 calcium-binding protein A6
SpeciesHuman
Gene ID-16277
UniprotP06703
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundS100 calcium binding protein A6(S100A6) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008],
Cellular LocalizationNuclear, Cytoplasmic
Tissue ExpressionBrain,Fibroblast,Placenta,Platelet,
Signaling_pathway
Research Areas
Functioninduction:Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.,miscellaneous:This protein co-purified with the prolactin receptor.,PTM:The N-terminus is blocked.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer, antiparallel. Interacts with SUGT1.,
RRID
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