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Background:The SIRPA gene encodes a receptor protein called Signal Regulatory Protein Alpha (SIRPA), which plays an important role in immune regulation and cell signaling. SIRPA regulates the activation level and immune response of cells by binding to the CD47 ligand on the surface of immune cells. Recent research on the SIRPA gene has shown its significance in tumor immune evasion, autoimmune diseases, neurodegenerative diseases, and other areas.






