Name: U-Blot® SOCS 2 Rabbit mAb
SKU: WR5984
Price: 268 USD
Availability: InStock

Product details

Background：
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway) . SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction , in part , by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines , including erythropoietin , GM-CSF , IL10 , interferon (IFN) -gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has

Specifications

Size	50μL/100μL
Target	SOCS-2
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	22kD
MW(Observed)	20kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1992R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	SOCS2
Protein Name	Suppressor of cytokine signaling 2
Other Name	SOCS2; / CIS2; / SSI2; / STATI2; / Suppressor of cytokine signaling 2; / SOCS-2; / Cytokine-inducible SH2 protein 2; / CIS-2; / STAT-induced STAT inhibitor 2; / SSI-2
Species	Human
Gene ID	8835
Uniprot	O14508,
Species.1	Mouse
Gene ID.1	216233
Uniprot.1	O35717,
Species.2	Rat
Gene ID.2	84607
Uniprot.2	O88582
Cellular Localization	cytoplasm,cytosol,
Tissue Expression	High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
Signaling_pathway	Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Research Areas	>>JAK-STAT signaling pathway; / >>Insulin signaling pathway; / >>Prolactin signaling pathway; / >>Type II diabetes mellitus; / >>Growth hormone synthesis, secretion and action
Function	Domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,Function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By a subset of cytokines, including erythropoietin and granulocyte-macrophage colony stimulating factor (GM-CSF).,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.,tissue specificity:High expression in heart, placenta, lung, kidney and prostate.,