Name: U-Blot® Stathmin Mouse mAb (Ready to Use)
SKU: WM1732R
Price: 168 USD
Availability: InStock

Product details

Background：
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],

Specifications

Target	Stathmin 1
Reactivity	Human, Mouse, Rat
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT266
Immunogen	Synthesized peptide derived from human Stathmin AA range: 1-100
Sequence
Specificity	The antibody can specifically recognize human Stathmin protein.
Gene Name	STMN1 C1orf215 LAP18 OP18
Protein Name	Stathmin
Other Name	Stathmin; / Leukemia-associated phosphoprotein p18; / Metablastin; / Oncoprotein 18; / Op18; / Phosphoprotein p19; / pp19; / Prosolin; / Protein Pr22; / pp17
Species	Human
Gene ID-1	3925
Uniprot	P16949,
Species.1	Mouse
Gene ID-2	16765
Uniprot.1	P54227,
Species.2	Rat
Gene ID-3	29332
Uniprot.2	P13668
Organism-4
Gene ID-4
SwissProt-4
Background	This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
Cellular Localization	Cytoplasmic
Tissue Expression	Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
Signaling_pathway	Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Research Areas	>>MAPK signaling pathway; / >>MicroRNAs in cancer
Function	Disease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,Function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.,similarity:Belongs to the stathmin family.,subunit:Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.,tissue specificity:Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver.,
RRID