U-Blot® STIP1/HOP Rabbit mAb
Ucallm_WR6051-50
Price range: $268.00 through $328.00
Product details
Background：
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90 , suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison , 2005 [PubMed 16100115]) .[supplied by OMIM , Jul 2009] ,
Specifications
| Size | 50μL/100μL |
| Target | STIP1/HOP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 63kD |
| MW(Observed) | 63kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2019R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | STIP1 |
| Protein Name | STIP1/HOP |
| Other Name | Stress-induced-phosphoprotein 1; / STI1; / Hsc70/Hsp90-organizing protein; / Hop; / Renal carcinoma antigen NY-REN-11; / Transformation-sensitive protein IEF SSP 3521 |
| Species | Human |
| Gene ID | 10963 |
| Uniprot | P31948, |
| Species.1 | Mouse |
| Gene ID.1 | 20867 |
| Uniprot.1 | Q60864, |
| Species.2 | Rat |
| Gene ID.2 | 192277 |
| Uniprot.2 | O35814 |
| Cellular Localization | Cytoplasm . Nucleus . Dynein axonemal particle . |
| Tissue Expression | B-cell lymphoma ,Brain ,Cajal-Retzius cell ,Epithelium ,Fetal brain cortex ,Kera |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Prion disease |
| Research Areas | >>Prion disease |
| Function | Domain:The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4 , 5 and 6 repeats (also called TPR2A domain) and TPR 7 , 8 and 9 repeats (also called TPR2B domain) interact with HSP90. ,Function:Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB) . ,similarity:Contains 2 STI1 domains. ,similarity:Contains 9 TPR repeats. ,subunit:Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG. , |
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