Price range: $268.00 through $328.00
Background:The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
| Size | 50μL/100μL |
| Target | STX3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 33kD |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1322R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | STX3 STX3A |
| Protein Name | STX3 |
| Other Name | |
| Species | Human |
| Gene ID | 6809 |
| Uniprot | Q13277, |
| Species.1 | Mouse |
| Gene ID.1 | 20908 |
| Uniprot.1 | Q64704, |
| Species.2 | Rat |
| Gene ID.2 | 81802 |
| Uniprot.2 | Q08849 |
| Cellular Localization | [Isoform A]: Apical cell membrane; Single-pass type IV membrane protein . Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. .; [Isoform 3]: Nucleus . |
| Tissue Expression | [Isoform A]: Expressed in small intestine, kidney, pancreas, placenta as well as in retina. Weaker expression in lung, liver and heart. Not expressed in brain and skeletal muscle.; [Isoform B]: Expressed only in the retina.; [Isoform 3]: Ubiquitously expressed. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>SNARE interactions in vesicular transport; / >>Synaptic vesicle cycle |
| Function | Function:Potentially involved in docking of synaptic vesicles at presynaptic active zones.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain., |
