Name: U-Blot® Synuclein-α (Phospho Ser129) Rabbit mAb
SKU: WR4840
Price: 288 USD
Availability: InStock

U-Blot® Synuclein-α (Phospho Ser129) Rabbit mAb

Ucallm_WR4840-50

Price range: $288.00 through $368.00

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SKU: WR4840-100

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Product details

Background:Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],

Specifications

Target	Synuclein-α
Reactivity	Human,Mouse,Rat
Applications	WB,IF,IP,ELISA
MW(Calculated)	14kD
MW(Observed)	18kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Phospho
Modification Site	Ser129
Recommended Dilution Ratio	WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Protein A
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Clonality	Monoclonal
Clone Number	PT1002R
Specificity	Synuclein-α (Phospho Ser129) Antibody detects endogenous levels of Synuclein-α protein only when phosphorylated at S129.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MPsEE
Gene Name	SNCA
Protein Name	Alpha-synuclein
Other Name	SNCA;NACP;PARK1;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Organism-1	Human
Gene ID-1	6622
SwissProt-1	P37840
Organism-2	Mouse
Gene ID-2	20617
SwissProt-2	O55042
Organism-3	Rat
Gene ID-3	29219
SwissProt-3	P37377
Organism-4
GeneID-4
SwissProt-4
Cellular Localization	Cytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .
Unnamed: 33