U-Blot® TCF-4 Rabbit mAb
Ucallm_WR5777-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TCF-4 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 71kD |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1740R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TCF4 |
| Protein Name | Transcription factor 4 |
| Other Name | TCF4; / BHLHB19; / ITF2; / SEF2; / Transcription factor 4; / TCF-4; / Class B basic helix-loop-helix protein 19; / bHLHb19; / Immunoglobulin transcription factor 2; / ITF-2; / SL3-3 enhancer factor 2; / SEF-2 |
| Species | Human |
| Gene ID | 6925 |
| Uniprot | P15884, |
| Species.1 | Mouse |
| Gene ID.1 | 21413, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 84382 |
| Uniprot.2 | Q62655 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in TCF4 are a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954].,Disease:Haploinsufficiency of TCF4 is a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954]. PTHS is a rare syndromic encephalopathy characterized by severe psychomotor delay, epilepsy, daily bouts of diurnal hyperventilation starting in infancy, mild postnatal growth retardation, postnatal microcephaly, and distinctive facial features. Since most hitherto reported cases have been sporadic, with males and females equally affected, PTHS is regarded as an autosomal dominant condition.,Function:Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.,sequence Caution:Incomplete and probable erroneous sequence.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2.,tissue specificity:Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain., |
Please login to post questions
Related products
