Price range: $268.00 through $328.00
Background：
This nuclear gene encodes a mitochondrial member of the thioredoxin family , a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq , Jul 2008] ,
| Size | 50μL/100μL |
| Target | THIOM |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 18kD |
| MW(Observed) | 12kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2010R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TXN2 TRX2 |
| Protein Name | Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2) |
| Other Name | |
| Species | Human |
| Gene ID | 25828 |
| Uniprot | Q99757, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P97493, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P97615 |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Widely expressed in adult (at protein level) and fetal tissues. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | >>NOD-like receptor signaling pathway; / >>Parkinson disease; / >>Salmonella infection; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. ,similarity:Belongs to the thioredoxin family. ,similarity:Contains 1 thioredoxin domain. ,subunit:Monomer. ,tissue specificity:Widely expressed in adult (at protein level) and fetal tissues. , |
