U-Blot® TIMP1 Rabbit mAb (Ready to Use)
Ucallm_WR8109
$168.00
Product details
Background：
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008],
Specifications
| Size | 6mL |
| Target | TIMP1 |
| Reactivity | Human |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | Recombinant Expression and Affinity purified |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM200R |
| Immunogen | Synthesized peptide derived from human Tissue Inhibitor of Metalloproteinases 1(TIMP1) AA range:50-150 |
| Specificity | This antibody detects endogenous levels of TIMP1 |
| Gene Name | TIMP1 |
| Protein Name | Tissue Inhibitor of Metalloproteinases 1(TIMP1) |
| Other Name | Metalloproteinase inhibitor 1; / Erythroid-potentiating activity; / EPA; / Fibroblast collagenase inhibitor; / Collagenase inhibitor; / Tissue inhibitor of metalloproteinases 1; / TIMP-1; / TIMP1; / CLGI; / TIMP |
| Species | Human |
| Gene ID | 7076 |
| Uniprot | P01033 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Detected in rheumatoid synovial fluid (at protein level). |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway |
| Research Areas | >>HIF-1 signaling pathway |
| Function | Function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.,PTM:The activity of TIMP1 is dependent on the presence of disulfide bonds.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain., |
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