Name: U-Blot® TLR1 Polyclonal Antibody
SKU: WP25021
Price: 268 USD
Availability: InStock

U-Blot® TLR1 Polyclonal Antibody

Ucallm_WP25021-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WP25021-50

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Product details

Background：
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TLR1
Reactivity	Human, Mouse, Rat
Applications	IHC, IF
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-500; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Polyclonal
Clone Number
Immunogen	Recombinant Protein of TLR1
Specificity	The antibody detects endogenous TLR1 protein.
Gene Name	TLR1
Protein Name	Toll-like receptor 1
Other Name	TLR1; / KIAA0012; / Toll-like receptor 1; / Toll/interleukin-1 receptor-like protein; / TIL; / CD281
Species	Human
Gene ID	7096
Uniprot	Q15399,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9EPQ1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein . Membrane raft . Golgi apparatus . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. .
Tissue Expression	Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Signaling_pathway	Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Research Areas	>>Toll-like receptor signaling pathway; / >>Tuberculosis
Function	Function:Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds MYD88 (via TIR domain) (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.,tissue specificity:Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.,