Price range: $268.00 through $328.00
Background:This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009],
| Size | 50μL/100μL |
| Target | TROP-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 36kD |
| MW(Observed) | 45-65kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:10000-1:50000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1308R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TACSTD2 |
| Protein Name | Tumor-associated calcium signal transducer 2 |
| Other Name | TACSTD2; / GA733-1; / M1S1; / TROP2; / Tumor-associated calcium signal transducer 2; / Cell surface glycoprotein Trop-2; / Membrane component chromosome 1 surface marker 1; / Pancreatic carcinoma marker protein GA733-1 |
| Species | Human |
| Gene ID | 4070 |
| Uniprot | P09758, |
| Species.1 | Mouse |
| Gene ID.1 | 56753 |
| Uniprot.1 | Q8BGV3, |
| Species.2 | Rat |
| Gene ID.2 | 494343 |
| Uniprot.2 | Q6P9Z6 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Placenta, pancreatic carcinoma cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment.,Function:GA733 tumor-associated antigen gene family may function as growth factor receptors.,PTM:The N-terminus is blocked.,similarity:Contains 1 thyroglobulin type-1 domain.,tissue specificity:Placenta, pancreatic carcinoma cell lines., |
