U-Blot® USP11 Rabbit mAb
Ucallm_WR6064-50
Price range: $268.00 through $328.00
Product details
Background：
Protein ubiquitination controls many intracellular processes , including cell cycle progression , transcriptional activation , and signal transduction. This dynamic process , involving ubiquitin conjugating enzymes and deubiquitinating enzymes , adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq , Jul 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | USP11 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 110kD |
| MW(Observed) | 125kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1939R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | USP11 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 11 |
| Other Name | USP11; / UHX1; / Ubiquitin carboxyl-terminal hydrolase 11; / Deubiquitinating enzyme 11; / Ubiquitin thioesterase 11; / Ubiquitin-specific-processing protease 11 |
| Species | Human |
| Gene ID | 8237 |
| Uniprot | P51784, |
| Species.1 | Mouse |
| Gene ID.1 | 236733 |
| Uniprot.1 | Q99K46 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). . |
| Tissue Expression | Brain,Fetal brain,Muscle,Retina, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM., |
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