Product details
Background:
function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo., miscellaneous:A cysteine residue is required for ubiquitin-thioester formation., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 1 IQ domain., subunit:Interacts with 26S proteasomes. Binds CAND2., tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.,
