SKU: WP14924 Categories: ,

Ubiquilin-3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14924-100
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Product details

Background:

Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetUbiquilin-3
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)70kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human UBQLN3. AA range:271-320
SpecificityUbiquilin-3 Polyclonal Antibody detects endogenous levels of Ubiquilin-3 protein.
Gene NameUBQLN3
Protein NameUbiquilin-3
Other NameUBQLN3; / Ubiquilin-3
SpeciesHuman
Gene ID50613
UniprotQ9H347,
Species.1Mouse
Gene ID.1244178
Uniprot.1Q8C5U9
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Tissue ExpressionTestis specific.
Signaling_pathwayHuman Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas>>Protein processing in endoplasmic reticulum; / >>Amyotrophic lateral sclerosis
Functionsimilarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,tissue specificity:Testis specific.,
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