UBP10 Polyclonal Antibody
Ucallm_WP1884-50
Price range: $268.00 through $328.00
Product details
Background:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013],
Specifications
| Size | 50μL/100μL |
| Target | UBP10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 87kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBP10 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | USP10 KIAA0190 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 10 (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) |
| Other Name | |
| Species | Human |
| Gene ID | 9100 |
| Uniprot | Q14694, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P52479, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q3KR59 |
| Cellular Localization | Cytoplasm . Nucleus . Early endosome . Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with G3BP, which may regulate its function.,tissue specificity:Widely expressed., |
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