Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
| Size | 50μL/100μL |
| Target | UBP4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human UBP4 AA range: 155-205 |
| Specificity | This antibody detects endogenous levels of UBP4 at Human/Mouse/Rat |
| Gene Name | USP4 UNP UNPH |
| Protein Name | UBP4 |
| Other Name | Ubiquitin carboxyl-terminal hydrolase 4; / Deubiquitinating enzyme 4; / Ubiquitin thioesterase 4; / Ubiquitin-specific-processing protease 4; / Ubiquitous nuclear protein homolog |
| Species | Human |
| Gene ID | 7375 |
| Uniprot | Q13107, |
| Species.1 | Mouse |
| Gene ID.1 | 22258 |
| Uniprot.1 | P35123, |
| Species.2 | Rat |
| Gene ID.2 | 290864 |
| Uniprot.2 | B2GUZ1 |
| Cellular Localization | Cytoplasm . Nucleus . Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. . |
| Tissue Expression | Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain., |
