UBP6 Polyclonal Antibody
Ucallm_WP1898-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol., disease:Involved in tumorigenesis., function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity., miscellaneous:The USP6 gene only exists in the primate lineage., similarity:Belongs to the peptidase C19 family., similarity:Contains 1 Rab-GAP TBC domain., tissue specificity:Testis specific. Expressed in various cancer cell lines.,
Specifications
| Size | 50μL/100μL |
| Target | UBP6 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 154kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBP6 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | USP6 HRP1 TRE2 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 6 (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) |
| Other Name | |
| Species | Human |
| Gene ID | 9098 |
| Uniprot | P35125 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton. |
| Tissue Expression | Testis specific. Expressed in various cancer cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Disease:Involved in tumorigenesis.,Function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.,miscellaneous:The USP6 gene only exists in the primate lineage.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Testis specific. Expressed in various cancer cell lines., |
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