Price range: $268.00 through $328.00
Background:
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | UBS3B |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 71kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBS3B Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | UBASH3B KIAA1959 STS1 |
| Protein Name | Ubiquitin-associated and SH3 domain-containing protein B (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) |
| Other Name | |
| Species | Human |
| Gene ID | 84959 |
| Uniprot | Q8TF42, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BGG7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Brain,Kidney,Liver,Placenta,Platelet, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins., |
