Product details
Background:
UBXD1 rabbit pAb
Ucallm_WP6457-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | UBXN6 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human UBXD1 |
| Specificity | This antibody detects endogenous levels of UBXD1 at Human, Mouse |
| Gene Name | UBXN6 UBXD1 UBXDC2 |
| Protein Name | UBX domain-containing protein 6 (UBX domain-containing protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 80700 |
| Uniprot | Q9BZV1, |
| Species.1 | Mouse |
| Gene ID.1 | 66530 |
| Uniprot.1 | Q99PL6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, cytosol . Membrane; Peripheral membrane protein . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Early endosome membrane; Peripheral membrane protein . Late endosome membrane; Peripheral membrane protein . Lysosome membrane; Peripheral membrane protein . Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). . |
| Tissue Expression | Enhanced expression in testis. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | |
| Function | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes . |
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