uPA Polyclonal Antibody
Ucallm_WP14940-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
Specifications
| Size | 50μL/100μL |
| Target | uPA |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human uPA. AA range:190-239 |
| Specificity | uPA Polyclonal Antibody detects endogenous levels of uPA protein. |
| Gene Name | PLAU |
| Protein Name | Urokinase-type plasminogen activator |
| Other Name | PLAU; / Urokinase-type plasminogen activator; / U-plasminogen activator; / uPA |
| Species | Human |
| Gene ID | 5328 |
| Uniprot | P00749, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P06869 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Expressed in the prostate gland and prostate cancers. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway |
| Research Areas | >>NF-kappa B signaling pathway; / >>Complement and coagulation cascades; / >>Transcriptional misregulation in cancer; / >>Proteoglycans in cancer; / >>MicroRNAs in cancer; / >>Prostate cancer |
| Function | Catalytic activity:Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.,Function:Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.,online information:Urokinase entry,pharmaceutical:Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders.,PTM:Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 peptidase S1 domain.,subunit:Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.,tissue specificity:Expressed in the prostate gland and prostate cancers., |
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