Name: U-Blot® UPB1 Rabbit mAb
SKU: WR4712
Price: 268 USD
Availability: InStock

U-Blot® UPB1 Rabbit mAb

Western Blot analysis of HeLa whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-UPB1 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4712 Western Blot analysis of HeLa whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-UPB1 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

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50μl

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SKU: WR4712-50

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Product details

Background:This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]

Specifications

Size	50μL/100μL
Target	UPB1
Reactivity	Human
Applications	WB, IHC, IP
MW(Calculated)
MW(Observed)	42kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-5000; IHC 1:100-300; IP 1:50-100 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0799R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	UPB1; BUP1
Protein Name	Beta-ureidopropionase; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
Other Name	UPB1; / BUP1; / Beta-ureidopropionase; / BUP-1; / Beta-alanine synthase; / N-carbamoyl-beta-alanine amidohydrolase
Species	Human
Gene ID	51733
Uniprot	Q9UBR1,
Species.1	Mouse
Gene ID.1	103149
Uniprot.1	Q8VC97,
Species.2	Rat
Gene ID.2	116593
Uniprot.2	Q03248
Cellular Localization	Cytoplasm.
Tissue Expression	Detected in liver (at protein level). {ECO:0000269\|PubMed:22525402}.
Signaling_pathway
Research Areas
Function	Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10415095, PubMed:10542323, PubMed:11508704, PubMed:22525402, PubMed:24526388, PubMed:29976570). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). {ECO:0000269\|PubMed:10415095, ECO:0000269\|PubMed:10542323, ECO:0000269\|PubMed:11508704, ECO:0000269\|PubMed:22525402, ECO:0000269\|PubMed:24526388, ECO:0000269\|PubMed:29976570, ECO:0000305\|PubMed:22525402, ECO:0000305\|PubMed:24526388}.