Product details
Background:
URM1 rabbit pAb
Ucallm_WP7023-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | URM1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 11kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human URM1 |
| Specificity | This antibody detects endogenous levels of URM1 at Human, Mouse |
| Gene Name | URM1 C9orf74 |
| Protein Name | Ubiquitin-related modifier 1 homolog |
| Other Name | |
| Species | Human |
| Gene ID | 81605 |
| Uniprot | Q9BTM9, |
| Species.1 | Mouse |
| Gene ID.1 | 68205 |
| Uniprot.1 | Q9D2P4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Sulfur relay system |
| Research Areas | |
| Function | Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. |
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