UVRAG Polyclonal Antibody
Ucallm_WP2328-50
Price range: $268.00 through $328.00
Product details
Background:
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | UVRAG |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 76kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein. AA range 655-675 |
| Specificity | UVRAG Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | UVRAG |
| Protein Name | UV radiation resistance-associated gene protein (p63) |
| Other Name | |
| Species | Human |
| Gene ID | 7405 |
| Uniprot | Q9P2Y5 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Late endosome . Lysosome . Cytoplasmic vesicle, autophagosome . Early endosome . Endoplasmic reticulum . Midbody . Chromosome, centromere . Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502). . |
| Tissue Expression | Highly expressed in brain, lung, kidney and liver. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal |
| Research Areas | >>Autophagy - animal |
| Function | Disease:Disrupted by a Inv(11)(q13.5; q25) inversion in a patient with heterotaxy (left-right axis malformation).,similarity:Contains 1 C2 domain.,tissue specificity:Highly expressed in brain, lung, kidney and liver., |
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