Name: V-ATPase D Polyclonal Antibody
SKU: WP14977
Price: 268 USD
Availability: InStock

V-ATPase D Polyclonal Antibody

Ucallm_WP14977-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14977-100

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Product details

Background:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	V-ATPase D
Reactivity	Human, Mouse, Rat, Swine
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	28kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from V-ATPase D . at AA range: 70-150
Specificity	V-ATPase D Polyclonal Antibody detects endogenous levels of V-ATPase D protein.
Gene Name	ATP6V1D
Protein Name	V-type proton ATPase subunit D
Other Name	ATP6V1D; / ATP6M; / VATD; / V-type proton ATPase subunit D; / V-ATPase subunit D; / V-ATPase 28 kDa accessory protein; / Vacuolar proton pump subunit D
Species	Human
Gene ID	51382
Uniprot	Q9Y5K8,
Species.1	Mouse
Gene ID.1	73834
Uniprot.1	P57746
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium . Localizes to centrosome and the base of the cilium. .
Tissue Expression	Bone marrow,Brain,Heart,Pancreatic adenocarcinoma,Pituitary,Placent
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas	>>Oxidative phosphorylation; / >>Metabolic pathways; / >>Phagosome; / >>mTOR signaling pathway; / >>Synaptic vesicle cycle; / >>Collecting duct acid secretion; / >>Vibrio cholerae infection; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Human papillomavirus infection; / >>Rheumatoid arthritis
Function	Function:Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.,similarity:Belongs to the V-ATPase D subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,