Name: V-ATPase D1 Polyclonal Antibody
SKU: WP15125
Price: 268 USD
Availability: InStock

V-ATPase D1 Polyclonal Antibody

Ucallm_WP15125-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15125-100

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Product details

Background:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [pro

Specifications

Size	50μL/100μL
Target	V-ATPase D1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	40kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human V-ATPase D1. AA range:221-270
Specificity	V-ATPase D1 Polyclonal Antibody detects endogenous levels of V-ATPase D1 protein.
Gene Name	ATP6V0D1
Protein Name	V-type proton ATPase subunit d 1
Other Name	ATP6V0D1; / ATP6D; / VPATPD; / V-type proton ATPase subunit d 1; / V-ATPase subunit d 1; / 32 kDa accessory protein; / V-ATPase 40 kDa accessory protein; / V-ATPase AC39 subunit; / p39; / Vacuolar proton pump subunit d 1
Species	Human
Gene ID	9114
Uniprot	P61421,
Species.1	Mouse
Gene ID.1	11972
Uniprot.1	P51863
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane; Peripheral membrane protein; Cytoplasmic side . Lysosome membrane; Peripheral membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein . Localizes to centrosome and the base of the cilium. .
Tissue Expression	Ubiquitous.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Immune disease >> Rheumatoid arthritis
Research Areas	>>Oxidative phosphorylation; / >>Metabolic pathways; / >>Lysosome; / >>Phagosome; / >>Synaptic vesicle cycle; / >>Collecting duct acid secretion; / >>Vibrio cholerae infection; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Tuberculosis; / >>Human papillomavirus infection; / >>Viral carcinogenesis; / >>Rheumatoid arthritis
Function	Function:Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.,similarity:Belongs to the V-ATPase V0D/AC39 subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Ubiquitous.,