V-ATPase S1 Polyclonal Antibody
Ucallm_WP15989-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013],
Specifications
| Size | 50μL/100μL |
| Target | V-ATPase S1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 51kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human V-ATPase S1. at AA range: 421-470 |
| Specificity | V-ATPase S1 Polyclonal Antibody detects endogenous levels of V-ATPase S1 |
| Gene Name | ATP6AP1 |
| Protein Name | V-ATPase S1 |
| Other Name | V-type proton ATPase subunit S1; / V-ATPase subunit S1; / Protein XAP-3; / V-ATPase Ac45 subunit; / V-ATPase S1 accessory protein; / Vacuolar proton pump subunit S1 |
| Species | Human |
| Gene ID | 537 |
| Uniprot | Q15904, |
| Species.1 | Mouse |
| Gene ID.1 | 54411 |
| Uniprot.1 | Q9R1Q9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein . Not detected in trans-Golgi network. . |
| Tissue Expression | widely expressed, with highest levels in brain and lowest in liver and duodenum. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Human Diseases >> Immune disease >> Rheumatoid arthritis |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Lysosome; / >>Phagosome; / >>Vibrio cholerae infection; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Tuberculosis; / >>Hepatitis B; / >>Human papillomavirus infection; / >>Rheumatoid arthritis |
| Function | Function:Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the vacuolar ATPase subunit S1 family.,subunit:Composed of at least 10 subunits.,tissue specificity:Ubiquitous., |
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